ODCs

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1 OMIM reference -
5 associated genes
9 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
8 signs/symptoms

Cystic fibrosis

Dilated cardiomyopathy - hypergonadotropic hypogonadism


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CFTR	(0.63)	LMNA

Citations in the biomedical literature:

Cystic fibrosis		Dilated cardiomyopathy - hypergonadotropic hypogonadism
	Synonym(s): - CF - Mucoviscidosis		Synonym(s): - Cardiogenital syndrome - Malouf syndrome - Najjar syndrome

	Classification (Orphanet): - Rare gastroenterologic disease - Rare genetic disease - Rare infertility - Rare respiratory disease		Classification (Orphanet): - Rare cardiac disease - Rare endocrine disease - Rare genetic disease - Rare infertility

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: neonatal/infancy Average age of death: young adult Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - 1 MeSH reference: D003550		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal recessive inheritance

Cystic fibrosis		Dilated cardiomyopathy - hypergonadotropic hypogonadism
	Very frequent - Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency - Immunodeficiency / increased susceptibility to infections / recurrent infections - Lung fibrosis - Malabsorption / chronic diarrhea / steatorrhea - Repeat respiratory infections - Structural anomalies of the liver and the biliary tract - Structural anomalies of the pancreas Occasional - Hepatomegaly / liver enlargement (excluding storage disease)		Very frequent - Abnormal / polycystic ovaries - Broad nose / nasal bridge - Cardiomyopathy / hypertrophic / dilated - Decreased body hair / axillar / pubic hairlessness - Late puberty / hypogonadism / hypogenitalism - Precocious puberty - Ptosis